tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate
tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate
CAS: 411238-88-5
Molecular Formula: C10H19N3O3
tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate - Names and Identifiers
tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate - Physico-chemical Properties
| Molecular Formula | C10H19N3O3 |
| Molar Mass | 229.28 |
| Density | 1.180±0.06 g/cm3(Predicted) |
| Boling Point | 395.8±31.0 °C(Predicted) |
| Flash Point | 193.1°C |
| Vapor Presure | 1.8E-06mmHg at 25°C |
| pKa | 13.04±0.20(Predicted) |
| Storage Condition | Room Temprature |
| Refractive Index | 1.514 |
tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Hazard Class | IRRITANT |
tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate - Introduction
tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate is an organic compound whose chemical formula is C12H21N3O3. It has the following properties:
1. Appearance: White crystalline solid.
2. Melting point: about 90-95°C.
3. Solubility: Soluble in organic solvents such as dimethylformamide (DMF) and dichloromethane.
tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate have many uses in the field of drug synthesis, including the following:
1. Provide hydrazine group: Hydrazine group is a commonly used reaction intermediate, which can be used to synthesize other biologically active compounds.
2. protection of nitrogen atom: by Boc(t-butoxycarbonyl) protecting group, the nitrogen atom in the compound can be selectively protected to prevent them from accidental reaction during the reaction.
3. Synthesis of targeted drugs: tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate can be used to synthesize compounds with specific drug target activity from lead compounds.
The preparation method of tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate generally includes the following steps:
1. First, pyrrolidine undergoes a base-catalyzed ring-closing reaction to generate 3-pyrrolidine formaldehyde.
2. Next, 3-pyrrolidinecarboxaldehyde is reacted with hydrazine to form the product tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate.
Regarding safety information, tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate currently has no specific hazard information publicly available. However, as a chemical, use should follow general laboratory safety practices, ensure good ventilation, and use personal protective equipment, such as laboratory gloves and protective glasses.
1. Appearance: White crystalline solid.
2. Melting point: about 90-95°C.
3. Solubility: Soluble in organic solvents such as dimethylformamide (DMF) and dichloromethane.
tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate have many uses in the field of drug synthesis, including the following:
1. Provide hydrazine group: Hydrazine group is a commonly used reaction intermediate, which can be used to synthesize other biologically active compounds.
2. protection of nitrogen atom: by Boc(t-butoxycarbonyl) protecting group, the nitrogen atom in the compound can be selectively protected to prevent them from accidental reaction during the reaction.
3. Synthesis of targeted drugs: tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate can be used to synthesize compounds with specific drug target activity from lead compounds.
The preparation method of tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate generally includes the following steps:
1. First, pyrrolidine undergoes a base-catalyzed ring-closing reaction to generate 3-pyrrolidine formaldehyde.
2. Next, 3-pyrrolidinecarboxaldehyde is reacted with hydrazine to form the product tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate.
Regarding safety information, tert-butyl 3-(hydrazinocarbonyl)pyrrolidine-1-carboxylate currently has no specific hazard information publicly available. However, as a chemical, use should follow general laboratory safety practices, ensure good ventilation, and use personal protective equipment, such as laboratory gloves and protective glasses.
Last Update：2024-04-09 21:01:54
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Product Name: 3-HYDRAZINOCARBONYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Visit Supplier Webpage Request for quotation
CAS: 411238-88-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 411238-88-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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